Penn's Institute for Immunology & Immune Health

Standardized Immune Profiling from Blood Draw to Insight

High-dimensional CyTOF and spectral flow cytometry with integrated data management on Pennsieve. One pipeline. Thousands of comparable profiles.

See How It Works
4,000+Patient Visits Profiled
50Immune Populations
30+MDIPA Markers
<48hDraw → Analysis
Your Project Journey

From Inquiry to Immune Fingerprint

Four phases connect your research question to a fully analyzed, QC-validated immune profile on Pennsieve.

1

Intake & Agreement

Submit your study details. We review scope, discuss objectives, and formalize a User Agreement.

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2

Sample Processing

Blood draw, PBMC isolation, and sample prep – standardized SOPs with chain-of-custody tracking.

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3

CyTOF & Analysis

MDIPA staining, CyTOF acquisition, EQ normalization, automated gating, and QC.

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4

Dashboard & Delivery

Track progress in real time. FCS files, QC reports, and Tier 1 analysis on your Pennsieve dashboard.

Partnership Opportunities

We work with academic institutions, biotech, and pharma partners to advance immune profiling research. If you're exploring a collaboration that leverages our standardized pipeline and 4,000+ patient dataset, we'd welcome a conversation.

Contact Partnerships →
The Science Team

Expertise Behind the Pipeline

Every sample is handled by specialists who've collectively built and validated the profiling platform across thousands of patients.

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Allie Greenplate, PhD
Director, Strategic Alliance
Architect of the I3H profiling platform – built the standardized pipeline from early concept to 4,000+ visits. Now focuses on strategic partnerships across pharma, biotech and academia, shaping the scientific direction of cross-institutional collaborations.
AB
Amy Baxter, DPhil
Scientific Director – Research & Assay Development
Drives assay development and research strategy for Immune Health – designing, testing and validating new assays, optimizing protocols and integrating the profiling pipeline into research studies.
SA
Sharon Adamski, MS
Biospecimen Processing
Manages end-to-end sample processing – from blood draw through PBMC isolation and cryopreservation. Maintains QC standards and chain-of-custody integrity across all active cohorts.
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Michelle McKeague, PhD
Platforms & Operations
Manages platform operations and investigator onboarding – scaling research assays into high throughput platforms approaches and coordinating new studies from initial consultation through sample receipt.
JW
Joost Wagenaar, PhD
Data Management – Pennsieve
Architect of the Pennsieve data platform at Penn. Leads FAIR-compliant data infrastructure connecting FCS files, clinical metadata, and provenance tracking across all I3H cohorts.
MI
Matei Ionita
Data Analytics
Develops the computational gating and "immune fingerprinting" algorithms – validated against expert immunologist gating – that turn raw data into individual immune profiles.
PartnershipsLeonardo Guercio · lguercio@pennmedicine.upenn.edu
BillingKenneth Hassinger · khas@pennmedicine.upenn.edu